Fingerprint lines may not directly affect SA-I mechanoreceptor response.
نویسندگان
چکیده
Understanding how skin microstructure affects slowly adapting type I (SA-I) mechanoreceptors in encoding edge discontinuities is fundamental to understanding our sense of touch. Skin microstructure, in particular papillary ridges, has been thought to contribute to edge and gap sensation. Cauna's 1954 model of touch sensibility describes a functional relationship between papillary ridges and edge sensation. His lever arm model proposes that the papillary ridge (exterior fingerprint line) and underlying intermediate ridge operate as a single unit, with the intermediate ridge acting as a lever which magnifies indentation imposed at the papillary ridge. This paper contests the validity of the lever arm model. While correctly representing the anatomy, this mechanism inaccurately characterizes the function of the papillary ridges. Finite element analysis and assessment of the critical anatomy indicate that papillary ridges have little direct effect on how SA-I receptors respond to the indentation of static edges. Our analysis supports a revised (stiff shell-elastic bending support) interpretation where the epidermis is split into two major layers with a stiff, deformable shell over an elastic bending support. Recent physiological, electrophysiological, and psychophysical findings support our conclusion that the function of the intermediate ridge is distinct from the function of the papillary ridge.
منابع مشابه
Discharge patterns of the slowly adapting mechanoreceptor afferent units innervating the non-warty skin of the frog.
Discharge patterns of slowly adapting (SA) mechanoreceptor afferent units innervating the non-warty skin of frogs, were analyzed statistically. Because SA units in the frog did not always produce sustained discharges for a long period, analysis was carried out on ensembles of interspike intervals (ISIs) obtained in two ways: (1) a series of successive ISIs obtained in the quasi-stationary state...
متن کاملCooling reduces the cutaneous afferent firing response to vibratory stimuli in glabrous skin of the human foot sole.
Skin on the foot sole plays an important role in postural control. Cooling the skin of the foot is often used to induce anesthesia to determine the role of skin in motor and balance control. The effect of cooling on the four classes of mechanoreceptor in the skin is largely unknown, and thus the aim of the present study was to characterize the effects of cooling on individual skin receptors in ...
متن کاملTitle: Cooling Reduces the Cutaneous Afferent Firing Response to Vibratory Stimuli in Corresponding Author
Skin on the foot sole plays an important role in postural control. Cooling the skin 23 of the foot is often used to induce anaesthesia to determine the role of skin in motor and 24 balance control. The effect of cooling on the four classes of mechanoreceptor in the skin is 25 largely unknown and thus the aim of the current study was to characterize the effects of 26 cooling on individual skin r...
متن کاملHuman sarcoma cell lines MES-SA and MES-SA/Dx5 as a model for multidrug resistance modulators screening.
The choice of cell lines for multidrug resistance (MDR) modulators screening may affect the results obtained. Screening is most often performed in model systems which employ cell lines derived from haematological malignancies. Cell lines originating from solid tumours are far less popular. In the present work, we aimed to test the usefulness of the drug-sensitive human sarcoma cell line MES-SA,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Somatosensory & motor research
دوره 25 1 شماره
صفحات -
تاریخ انتشار 2008